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KMID : 0383819830300010024
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Tuberculosis and Respiratory Diseases
1983 Volume.30 No. 1 p.24 ~ p.31
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The Interaction of Rifampicin in Association with Other Antimicrobial Drugs on Mycobacterium Fortuitum in vitro
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Kim Sang-Jae
Suh Ok-Ja
Bai Gill-Han
Jin Byung-Won
Kim Sung-Chin
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Abstract
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Selection of antimicrobial drugs effective on M, fortuitum and investigation on the interaction aspects of rifampicin with other antimicrobial drugs have been carried out using the drug concentrations which inhibited growth of 44 to 95% of cultivable cells. Total growth inhibition of approximately 4.3×l04 viable bacilli inoculated was obtained with 1.3nM of amikacin, 44.36nM of prothionamide, and 10.4nM of tetracycline. The association of 56% growth inhibitory concentration of rifampicin with 84% growth inhibitory concentration of ethambutol caused more than 99.9% reduction of viable cells which were survived by the treatment of either one drug alone. The simile synergistic effect was observed in the combination of rifampicin with prothionamide, but not much prominent with amikacin. Tetracycline seemed to act independently although some additive effect was clearly demonstrated.
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KEYWORD
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